Koşul
Freeze-drying is a gentle, but technically complex drying process during which moisture is extracted from the frozen goods under vacuum conditions. So, many liquid active pharmaceutical ingredients for the pharmaceutical industry are quickly deep-frozen at temperatures of -70 to -100°C. Then, the frozen material is dried in a vacuum chamber. The ice evaporates at underpressure without becoming liquid - it sublimates. The water vapour is then extracted at increased vacuum and higher temperatures. For some types, the encapsulation of the glass bottles containing the ingredient is carried out under clean room conditions. Of all types of drying, freeze-drying leads to the least product changes and losses of ingredients. Freeze-dryers operate in 3 steps: freezing, main drying, final drying. As from the second step, a vacuum pump is connected to the drying chamber to initiate the sublimation. Here, extreme parameters are reached. The vacuum sensor must withstand 5 x 10-3 mbar. This means no external particles must enter into the drying chamber, as they would contaminate the product.

Geri dönüşüm
Pressure sensors have to withstand the extreme vacuum of 5 x 10-3 mbar. Tests in ifm electronic\'s test laboratory confirm that the ifm vacuum sensors meet these requirements.

Müşteriye sağladığı yararlar
The manufacturing process can be certified for the pharmaceutical industry. A parameter protocol is available for CRF 21 part 11 products. Further regulations such as GMP and GAMP 4 can be complied with.